Scientists Identify ‘Rogue Antibodies’ Behind Severe Clotting With COVID

rouge antibodies

Rogue Antibodies: COVID-19 patients often come across with blood clotting and illness. Scientists have now identified antibodies responsible that trigger such symptoms. They have called them as rogue antibodies.


Before researchers came to conclusion, they analyzed the blood samples of as many as 244 patients who were hospitalized for COVID-19.

While analyzing blood samples of such patients, they came across circulating antiphospholipid antibodies that are specific types of autoantibodies meant attack a patient’s own systems and organs.

In most cases, these autoantibodies are found in patients suffering from autoimmune disorders like lupus. In a study, scientists found that these autoantibodies are activated in cases of viral infections.

At times, they also seem to activate some other immune responses. The original report was published in the journal Arthritis & Rheumatolog on February 17, 2022. Time has come where most researchers suggest people to go with COVID-19 booster dose.


Rogue Antibodies

While analyzing blood reports of COVID-19 patients, researchers found that they had somewhat higher levels of an antibody IgG as compared to people without COVID-19.

The very fact that antibody IgG works in association with other immune cells like IgM. Together they act in response to various immune threats. Scientists now call these antibodies as rogue antibodies.

Higher amounts of IgG were found to be associated with more severe COVID-19. Such people mostly require breathing assistance.

Researchers when removed IgG antibodies from the blood of COVID-19 patients, they observed a consistent decline in the molecular indicators of “blood vessel stickiness’.

And when they further tried to add IgG antibodies

to the original blood samples of COVID-19 patients, they again observed an increase in the inflammatory response of blood vessels responsible for clotting.

With the above findings, researchers concluded that since all body organs are made up of blood vessels, higher amounts of IgG can greatly enhance the inflammation and “stickiness” of blood vessels in people with COVID-19.

The above finding can help scientists find the reason why the coronavirus tends to damage a number of body organs like brain, lungs and heart. The above study was conducted by a team of doctors led by Dr. Yogen Kanthi, Laboratory of Vascular Thrombosis and Inflammation at the U.S. National Heart, Lung, and Blood Institute, said in a U.S.

To be precise, antibodies shown to cause clotting and breathing problems in patients with COVID-19 are known as rogue antibodies. Further studies are being conducted to know more effects of them.

Likewise, the researchers observed quite similar patterns after they chose to analyze as many as 100 patients suffering from a condition called sepsis. The above condition has a tendency to leave the body in state of inflammatory shock after a viral or bacterial infection.






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