Studies Detect Overactive Cell Metabolism Associated With Biological Ageing

Overactive Cell Metabolism: Do you know why our cells or we age with time? As far as studies conducted in this regard, the concept of aging relates to mitochondria, an organelle that provides energy to cells.

Now, as per a new study published in the Communications Biology, researchers at the Columbia University have revealed that human cells having impaired mitochondria behave by expending more energy.

This adaptation of cells comes with somewhat dramatic increase in the rate at which cells age.

Studies Detect Overactive Cell Metabolism Associated With Biological Ageing

Martin Picard, PhD, who’s the associate professor of behavioral medicine (in psychiatry and neurology) at Columbia University Vagelos College of Physicians and Surgeons says, “The findings were made in cells from patients with rare mitochondrial diseases, yet they may also have relevance for other conditions that affect mitochondria, including neurodegenerative diseases, inflammatory conditions, and infections,” he said.

He also observed that hypermetabolism may also be a reason for the deterioration of most cells as soon as we get older.

It’s mainly assumed that all defects related to mitochondria which plays a key role in impairing conversion of food into energy would obviously force them to slow their metabolic rate. And this happens to conserve their energy.

After swiftly analyzing data from patients having ailments related to mitochondria, it was known that patients having any sort of mitochondrial defects tends to enhance the overall energetic cost of living.

On one hand this energy source continues to boost energy to keep cells running, it also degrades their telomeres (caps that protect the ends of our chromosomes). This finally activates the inflammation and stress responses. And this results in the acceleration of biological aging.

This is what Gabriel Sturm, a lead author in this study has to say, “When cells expend more energy to make proteins and other substances essential for short-term survival, they’re likely stealing resources from processes that ensure long-term survival, like maintaining telomeres,” he said.






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